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一种可以防御不同亚型流感病毒的通用疫苗已接近成为现实!
发表时间:2017-2-15 14:00:13 浏览次数:

一种可以防御不同亚型流感病毒的通用疫苗已接近成为现实。美国国立卫生研究院的研究人员已经从H1N1流感病毒中开发出一种具有稳定血凝素(HA)刺突的纳米疫苗(1)。这种H1 HA刺突免疫原可诱发小鼠和雪貂体内的抗体交叉反应,从而避免因不同HA亚型感染(H5)导致的疾病发生。虽然该疫苗未引起广泛的病毒中和反应,但其保护机制经证实为抗体介导型。这些令人振奋的结果显示,该种仅含血凝素(HA)刺突的纳米疫苗可刺激潜在广泛的免疫反应,以抵御不同的流感病毒株。

中国投入流感病毒研究逐年上升,北京更是全球发表最多文献的城市。 GeneTex在流感抗体的开发不遗余力,为您准备一系列的优质抗体,请点击这里访问我们的网站,寻找您需要的抗体。您科研的好伙伴GeneTex。

 

Selected Antibodies for Influenza Virus

GeneTex has supported the world's leading researchers for over 15 years with our quality antibodies. Our products continue to be referenced in leading publications and we are proud to be able to contribute to the research community. In this GeneTex newsletter issue, we would like to highlight our catalog of Influenza virus antibodies. Influenza Virus Antibodies

There are three types of influenza virus: Types A, B, and C. The influenza A and B viruses are the ones most associated with serious human infections, while the Type C cases are clinically much milder. The main antigenic determinants of influenza A and B viruses are the hemagglutinin (HA) and neuraminidase (NA) transmembrane glycoproteins. Based on the antigenicity of these glycoproteins, influenza A viruses are further subdivided into sixteen "H" (H1-H16) and nine "N" (N1-N9) subtypes. The influenza A virus genome consists of eight separate RNA segments that encode the proteins (i.e., PB1, PB2, PA, HA, NA, NP, M1, M2, NS1, and NS2) essential for host infection, viral genome replication, and virus particle packaging.
 
FluA H1N1 HA (GTX127295)   FluA H5N3 HA (GTX127299)   FluA H7N7 HA (GTX127303)   FluA H9N2 HA (GTX127305)
FluA H1N1 HA (GTX127295)   FluA H5N3 HA (GTX127299)   FluA H7N7 HA (GTX127303)   FluA H9N2 HA (GTX127305)
WB analysis on MDCK cell lysates infected with different subtypes of human and avian influenza virus A by using influenza A Virus H1N1 HA antibody (GTX127295), influenza A Virus H5N3 HA antibody (GTX127299), influenza A virus H7N7 HA antibody (GTX127303), and influenza A virus H9N2 HA antibody (GTX127305).
 
Click here to view the full list of antibodies against Influenza virus proteins.
 
Product Highlight - Influenza A
Influenza A Virus NS1 antibody (GTX125990)   Influenza A Virus NP antibody (GTX125989)
Influenza A Virus NS1 antibody (GTX125990)   Influenza A Virus NP antibody (GTX125989)
ICC/IF analysis with Influenza A Virus NS1 antibody on Vero cells infected with influenza A virus (WSN).   ICC/IF analysis with Influenza A Virus NP antibody on Vero cells infected with influenza A virus (WSN).
Influenza A Virus H1N1 Hemagglutinin (HA) antibody [GT223] (GTX629750)   Influenza A Virus NP antibody [GT1236] (GTX629633)
Influenza A Virus H1N1 Hemagglutinin (HA) antibody [GT223] (GTX629750)   Influenza A Virus NP antibody [GT1236] (GTX629633)
ICC/IF analysis with Influenza A Virus H1N1 HA (FluA HA) antibody on DF1 cells infected with influenza A virus (WSN).   ICC/ IF analysis with influenza A Virus NP antibody on DF1 cells infected with influenza A virus (WSN).
Influenza A Virus M1 antibody (GTX125928)   Influenza A Virus M2 antibody (GTX125951)   Influenza A Virus NP antibody [GT1236] (GTX629633)   Influenza A Virus NS1 antibody (GTX125990)
Influenza A Virus M1 antibody (GTX125928)   Influenza A Virus M2 antibody (GTX125951)   Influenza A Virus NP antibody [GT1236] (GTX629633)   Influenza A Virus NS1 antibody (GTX125990)
WB analysis with Influenza A Virus M1 antibody on DF-1 cell lysate. (A) Mock control. (B) influena A virus (WSN) infection.   WB analysis with Influenza A Virus M2 antibody on DF-1 cell lysate. (A) Mock control. (B) influena A virus (WSN) infection.   WB analysis with Influenza A Virus NP antibody on DF-1 cell lysate. (A) Mock control. (B) influena A virus (WSN) infection.   WB analysis with Influenza A Virus NS1 antibody on DF-1 cell lysate. (A) Mock control. (B) influena A virus (WSN) infection.
Citation Cat. No. Product Name Host & Clonality Application
  GTX125951 Influenza A virus M2 (matrix protein) Rb pAb ICC/IF, WB
  GTX125989 Influenza A virus NP (nucleoprotein) Rb pAb ICC/IF, WB
  GTX629633 Influenza A virus NP (nucleoprotein) Ms mAb ICC/IF, WB
  GTX629544 Influenza A virus NP (nucleoprotein) Ms mAb WB
  GTX28261 Influenza A virus NP (nucleoprotein) Ms mAb ELISA, ICC/IF
Citation GTX125990 Influenza A virus NS1 (nonstructural protein) Rb pAb ICC/IF, WB
  GTX125952 Influenza A virus NS2 (nonstructural protein) Rb pAb WB
Citation GTX125953 Influenza A virus NS2 (nonstructural protein) Rb pAb WB
Citation GTX125932 Influenza A virus PA protein antibody Rb pAb ICC/IF, WB
  GTX125933 Influenza A virus PA protein antibody Rb pAb ICC/IF, WB
Citation GTX118991 Influenza A virus PA protein antibody Rb pAb ICC/IF, WB
Citation GTX125923 Influenza A virus PB1 protein antibody Rb pAb ICC/IF, WB
  GTX125925 Influenza A virus PB2 protein antibody Rb pAb ICC/IF, WB
  GTX125926 Influenza A virus PB2 protein antibody Rb pAb ICC/IF, WB
  GTX125928 Influenza A virus M1 (matrix protein) Rb pAb WB
Citation GTX127356 Influenza A virus M1 (matrix protein) Rb pAb ELISA, WB
  GTX127294 Influenza A virus H1N1 HA (Hemagglutinin) Rb pAb WB
  GTX127295 Influenza A virus H1N1 HA (Hemagglutinin) Rb pAb WB
  GTX127357 Influenza A virus H1N1 HA (Hemagglutinin) Rb pAb ICC/IF, WB
  GTX629750 Influenza A virus H1N1 HA (Hemagglutinin) antibody Ms mAb ICC/IF, WB
  GTX629746 Influenza A virus H1N1 HA (Hemagglutinin) antibody [GT521] Ms mAb WB
  GTX125974 Influenza A virus H1N1 NA (Neuraminidase) antibody Rb pAb WB
  GTX629695 Influenza A virus H1N1 NA (Neuraminidase) antibody [GT172] Ms mAb WB
  GTX629696 Influenza A virus H1N1 NA (Neuraminidase) antibody [GT288] Ms mAb ICC/IF, WB
  GTX127363 Influenza A virus H3N2 HA (Hemagglutinin) antibody Rb pAb IHC-P, WB
  GTX127984 Influenza A virus H5N1 NA (Neuraminidase) antibody Rb pAb WB
  GTX127302 Influenza A virus H7N7 HA (Hemagglutinin) antibody Rb pAb WB
  GTX127303 Influenza A virus H7N7 HA (Hemagglutinin) antibody Rb pAb WB
  GTX127305 Influenza A virus H9N2 HA (Hemagglutinin) antibody Rb pAb WB
  GTX127306 Influenza A virus H9N2 HA (Hemagglutinin) antibody Rb pAb WB
  GTX127307 Influenza A virus H9N2 HA (Hemagglutinin) antibody Rb pAb WB
  GTX127299 Avian Influenza A virus H5N3 HA (Hemagglutinin) antibody Rb pAb WB
 
Product Highlight - Influenza B
Influenza B Virus M antibody (GTX128537)   Influenza B Virus Neuraminidase (NA) antibody (GTX128540)
Influenza B Virus M antibody (GTX128537)   Influenza B Virus Neuraminidase (NA) antibody (GTX128540)
ICC/IF analysis with Influenza B Virus M antibody on MDCK cells infected with influenza B virus (Taiwan B70555).   ICC/IF analysis with Influenza B Virus Neuraminidase (NA) antibody on MDCK cells infected with influenza B virus (Taiwan B70555).
Influenza B Virus Hemagglutinin (HA) antibody (GTX128542)   Influenza B Virus NP antibody [GT371] (GTX629882)
Influenza B Virus Hemagglutinin (HA) antibody (GTX128542)   Influenza B Virus NP antibody [GT371] (GTX629882)
ICC/IF analysis with Influenza B Virus Hemagglutinin (HA) antibody on MDCK cells infected with influenza B virus (Taiwan B70555).   ICC/IF analysis with Influenza B Virus NP antibody on MDCK cells infected with influenza B virus.
Influenza B Virus M antibody (GTX128536)   Influenza B Virus NP antibody [GT371] (GTX629882)   Influenza B Virus Hemagglutinin (HA) antibody (GTX128542)   Influenza B Virus antibody (GTX128544)
Influenza B Virus M antibody (GTX128536)   Influenza B Virus NP antibody [GT371] (GTX629882)   Influenza B Virus Hemagglutinin (HA) antibody (GTX128542)   Influenza B Virus antibody (GTX128544)
WB analysis with Influenza B Virus M antibody. (A) Non-infection control. (B) Medium harvested from cells infected with Influenza B virus.   WB analysis with Influenza B Virus NP antibody on MDCK cells. (A) Non-infection control. (B) Infection of influenza B virus (Taiwan 70555)   WB analysis with Influenza B Virus Hemagglutinin (HA) antibody. (A) Non-infection control. (B) Medium harvested from cells infected with Influenza B virus.   WB analysis with Influenza B Virus antibody. (A) Non-infection control. (B) Medium harvested from cells infected with Influenza B virus.
Cat. No. Product Name Host & Clonality Application
GTX128544 Influenza B Virus antibody Rb pAb WB
GTX128536 Influenza B Virus M antibody Rb pAb WB
GTX128537 Influenza B Virus M antibody Rb pAb ICC/IF, WB
GTX128540 Influenza B Virus Neuraminidase (NA) antibody Rb pAb ICC/IF
GTX128541 Influenza B Virus Neuraminidase (NA) antibody Rb pAb ICC/IF
GTX629882 Influenza B Virus NP antibody [GT371] Ms mAb ICC/IF, WB
GTX629883 Influenza B Virus NP antibody [GT382] Ms mAb ICC/IF, WB
GTX128538 Influenza B Virus NP antibody Rb pAb ICC/IF, WB
GTX128539 Influenza B Virus NP antibody Rb pAb ICC/IF, WB
GTX128542 Influenza B Virus Hemagglutinin (HA) antibody Rb pAb ICC/IF, WB
GTX128543 Influenza B Virus Hemagglutinin (HA) antibody Rb pAb ICC/IF, WB